Often classified as an anti-estrogen, Tamoxifen Citrate functions both as an antagonist and agonist. This indicates it will inhibit estrogen activity in certain parts of the body while mimicking estrogen effects in others.
Used by many anabolic steroid users, Tamoxifen Citrate is not classified as a steroid. It is utilized during steroid cycles to alleviate estrogen-related side effects linked to particular steroids. However, its most prevalent use occurs during Post Cycle Therapy (PCT).
Effects of Tamoxifen
For users of anabolic steroids, the beneficial effects of Tamoxifen Citrate can be observed both during and after steroid use, with a greater emphasis on post-use. While it does not lower serum estrogen levels, it effectively binds to receptors in the chest area, thereby blocking estrogen from attaching. It may not significantly reduce water retention, and for some men, it may not provide sufficient protection against gynecomastia, which can depend on individual estrogen levels and genetic factors. For enhanced estrogen control, Aromatase Inhibitors (AIs) are often suggested.
Additionally, Tamoxifen Citrate also stimulates testosterone production, which is particularly essential for anabolic steroid users. The use of anabolic steroids suppresses the body’s natural testosterone production, leading to low testosterone levels without the inclusion of exogenous testosterone in most steroid cycles. After completing a steroid cycle, testosterone production needs to be rejuvenated, and although this process occurs naturally, Tamoxifen can accelerate and enhance its efficiency.
For breast cancer patients, the effects of Tamoxifen Citrate are generally more direct than for anabolic steroid users. Estrogen fuels the cancer growth, but Tamoxifen Citrate prevents estrogen from binding, effectively starving the cancer. This is a straightforward and effective treatment method. Typically, treatment begins with an AI and later transitions to a Selective Estrogen Receptor Modulator (SERM) like Tamoxifen Citrate. It can also be used as a preventive measure for those with a significant family history of breast cancer.
Side effects:Possible side effects include headaches, nausea, hot flashes, vaginal irritation, bleeding or discharge, skin rash, reduced white blood cell count, endometrial alterations, elevated triglyceride levels, and risks of pulmonary embolism.Administration:
In breast cancer treatment, there are six established Tamoxifen Citrate regimens that cater to both males and females. Generally, doses range from 10-20 mg taken twice daily. A common initial dosage is 40 mg daily (20 mg twice daily) during the beginning of treatment. Many breast cancer patients may continue with a dosage of 10-20 mg per day indefinitely once the cancer is in remission to help prevent recurrence.For anabolic steroid users focusing on gynecomastia prevention during cycles, a typical dosage ranges from 10-20 mg daily. If this dosage proves ineffective, it is advisable to consider AIs instead.
For PCT, most plans start with Tamoxifen Citrate dosages of 40 mg daily, continuing for 2-3 weeks. Following this, the dosage is typically reduced to 20 mg daily for an additional 2-3 weeks. A comprehensive PCT often includes another SERM, Clomiphene Citrate (Clomid). For complete PCT guidelines, please refer to "How to Come off Steroids."
