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Often categorized as an anti-estrogen, Tamoxifen Citrate serves as both an antagonist and agonist. This implies it inhibits estrogen activity in certain areas of the body while promoting it in others.

This medication is utilized by many users of anabolic steroids, although it is not classified as a steroid itself. It is frequently employed during steroid cycles to mitigate estrogen-related side effects stemming from particular steroids but is most commonly used during Post Cycle Therapy (PCT).

For anabolic steroid users, the beneficial effects of Tamoxifen Citrate can be observed both during and after steroid usage, with a primary focus on post-use. While it does not reduce serum estrogen levels, Tamoxifen Citrate attaches to receptors in the chest area, thereby blocking estrogen from binding. However, it may not significantly alleviate water retention concerns and may not provide sufficient gynecomastia protection for all individuals, as this depends on the degree of elevated estrogen levels and genetic factors. For those requiring stronger protection, Aromatase Inhibitors (AIs) are recommended.

Additionally, Tamoxifen Citrate has testosterone-stimulating properties, which is the most crucial aspect for anabolic steroid users. The use of anabolic steroids suppresses natural testosterone production, a phenomenon that occurs regardless of the type of steroids taken. This is why nearly all steroid cycles incorporate exogenous testosterone to prevent low testosterone levels due to negative feedback. After completing steroid use, a method is necessary to restart testosterone production, which, while it will eventually occur naturally, can be hastened and made more efficient with Tamoxifen.

For breast cancer patients, the effects of Tamoxifen Citrate may be more straightforward than for anabolic steroid users. Since estrogen fuels the cancer, Tamoxifen Citrate works by preventing this attachment, effectively starving the cancer. This approach is simple and effective in treatment. It is not the sole medication used, as treatment often starts with an AI before transitioning to a SERM like Tamoxifen Citrate. In some cases, it is also used as a preventive measure for individuals with a strong family history of breast cancer.

For breast cancer treatment, there are six different Tamoxifen Citrate protocols that cover both male and female patients. Typically, doses range between 10-20mg taken twice daily. A common regimen begins with 40mg per day (20mg twice daily) during the initial phase of treatment. Many breast cancer patients may continue with a maintenance dose of 10-20mg daily indefinitely once the cancer is in remission to prevent recurrence.For anabolic steroid users, the standard preventive dosage against gynecomastia ranges from 10-20mg per day. If this dosage is insufficient, it is unlikely that a higher dose will provide help, and the use of AIs should be strongly considered.

As for PCT use, most plans initiate with Tamoxifen Citrate at a dosage of 40mg per day for 2-3 weeks, followed by a reduction to 20mg daily for an additional 2-3 weeks. A complete PCT often includes another SERM, Clomiphene Citrate (Clomid). For detailed PCT guidance, please refer to "How to Come off Steroids."