NolvaActive ingredient: Tamoxifen CitrateAlso known as: Tamoxifene, Nolvadex, Tamox, Tamoximed, SoltamoxActive half-life 5-7 days
Often described as an anti-estrogen, Tamoxifen Citrate functions both as an antagonist and agonist. This indicates that it can block estrogen in certain parts of the body while mimicking it in others.
Although many anabolic steroid users take this medication, it is not a steroid itself. It is commonly utilized during steroid cycles to mitigate estrogen-related side effects associated with certain steroids, but it is primarily used in Post Cycle Therapy (PCT).
Effects of Tamoxifen
For users of anabolic steroids, the benefits of Tamoxifen Citrate can be apparent during and after steroid use, with a stronger emphasis on post-use. While it does not reduce serum estrogen levels, it attaches to receptors in the chest, preventing estrogen from binding effectively. It is not particularly effective for water retention issues and may not suffice for gynecomastia prevention for all individuals, as effectiveness depends on estrogen levels and genetics. If stronger protection is necessary, Aromatase Inhibitors (AIs) are advised.
Additionally, Tamoxifen Citrate stimulates testosterone production, which is crucial for anabolic steroid users. Anabolic steroid use typically suppresses natural testosterone levels, necessitating the inclusion of exogenous testosterone in most cycles to counteract low testosterone due to negative feedback. Post-steroid use, something is needed to reactivate testosterone production, which Tamoxifen can facilitate and enhance, although it will naturally occur over time.
For breast cancer patients, the effects of Tamoxifen Citrate are more direct. Estrogen can promote cancer growth, but Tamoxifen Citrate blocks its attachment, effectively starving the cancer. This straightforward method is part of a broader treatment strategy that often begins with an Aromatase Inhibitor and transitions to a Selective Estrogen Receptor Modulator (SERM) like Tamoxifen Citrate. It can also be used as a preventive measure for individuals with a significant family history of breast cancer.
Possible side effects:Headaches, nausea, hot flashes, vaginal itching, bleeding, discharge or discomfort, rash, lowered white blood cell count, endometrial changes, elevated triglyceride levels, pulmonary embolism.Usage guidelines:
In breast cancer treatment, there are six different plans for administering Tamoxifen Citrate, applicable to both men and women. Typically, the dosage ranges from 10-20mg taken twice a day. A common initial dosage is 40mg per day (20mg twice daily), with many patients continuing with 10-20mg daily for an extended period once remission is achieved to prevent recurrence.For anabolic steroid users, a dosage of 10-20mg per day is standard for gynecomastia prevention during a cycle. If this dosage is ineffective, it's unlikely that a higher dose will help, and the consideration of AIs is recommended.
Regarding PCT, most plans start with a 40mg daily dosage of Tamoxifen Citrate for 2-3 weeks before reducing to 20mg per day for another 2-3 weeks. A complete PCT regimen often incorporates another SERM, Clomiphene Citrate (Clomid). For a detailed PCT plan, refer to guidelines on how to discontinue steroid use.