Frequently labeled as an anti-estrogen, Tamoxifen Citrate functions both as an antagonist and agonist. This means it behaves as an anti-estrogen in certain body regions while mimicking estrogen in others.
It is a medication commonly used by anabolic steroid users, although it is not a steroid itself. This drug is often utilized during steroid cycles to counteract estrogen-related side effects associated with specific anabolic steroids, but it’s primarily used in Post Cycle Therapy (PCT).
Impact of Tamoxifen
For users of anabolic steroids, the beneficial effects of Tamoxifen Citrate can be observed both during and after steroid use, with post-use effects being more significant. While it does not decrease overall estrogen levels in the bloodstream, it attaches to receptors in the breast area, blocking estrogen from binding there. However, it might not be adequate for all men in preventing gynecomastia, depending on individual estrogen levels and genetic factors. For stronger protection, Aromatase Inhibitors (AIs) are advised.
Additionally, Tamoxifen Citrate has testosterone-stimulating effects, which are vital for anabolic steroid users. The use of anabolic steroids suppresses natural testosterone production, making it necessary to include exogenous testosterone in most cycles to avoid low testosterone levels. After completing steroid use, there's a need for a way to rejuvenate testosterone production. While this will eventually happen naturally, Tamoxifen can expedite and enhance this process.
For breast cancer patients, the effects of Tamoxifen Citrate are clearer. Estrogen promotes cancer growth, but Tamoxifen Citrate blocks its attachment, effectively starving the cancer cells. This straightforward yet effective treatment is often combined with other drugs; typically, an AI may be prescribed first, followed by a transition to a SERM such as Tamoxifen Citrate. It may also be used preventively for individuals with a strong family history of breast cancer.
Potential side effects:Headaches, digestive issues, hot flashes, vaginal itching, bleeding, discharge or discomfort, rash, reduced white blood cell count, changes in the endometrium, increased triglyceride levels, and risk of pulmonary embolism.Administration:
For treating breast cancer, there are six Tamoxifen Citrate protocols for both male and female patients. Typically, dosages fall between 10-20 mg taken twice daily. A common initial dosage is 40 mg daily (20 mg twice daily). Many breast cancer patients may continue taking 10-20 mg per day indefinitely after remission to prevent recurrence.For anabolic steroid users, the standard dosage for preventing gynecomastia during cycles is between 10-20 mg daily. If this range is ineffective, it's unlikely that higher doses will be beneficial, and AIs should be considered.
For Post Cycle Therapy (PCT), most regimens start with Tamoxifen Citrate at 40 mg daily for 2-3 weeks, after which the dose is reduced to 20 mg daily for another 2-3 weeks. A comprehensive PCT program often includes an additional SERM, Clomiphene Citrate (Clomid). For a detailed PCT guide, refer to "How to Come off Steroids."