Commonly recognized as an anti-estrogen, Tamoxifen Citrate functions as both an antagonist and agonist. This dual action allows it to inhibit estrogen in some areas while mimicking it in others.
Often utilized by users of anabolic steroids, Tamoxifen Citrate is not classified as a steroid itself. Steroid users may take it to mitigate estrogen-related side effects resulting from certain steroids, but its primary application is during Post Cycle Therapy (PCT).
Effects of Tamoxifen:
For anabolic steroid users, the benefits of Tamoxifen Citrate can be observed during and especially after steroid cycles. While it does not lower serum estrogen levels, it binds to receptors in the breast tissue, blocking estrogen from attaching. However, it may not significantly address issues like water retention or be sufficient for all men to prevent gynecomastia, which can vary based on estrogen levels and individual genetics. In cases requiring stronger estrogen control, Aromatase Inhibitors (AIs) are usually advised.
Moreover, Tamoxifen Citrate has testosterone-stimulating effects, which are crucial for anabolic steroid users. Anabolic steroids suppress natural testosterone production, making it essential to include exogenous testosterone during cycles to counteract low testosterone levels. After completing steroid use, something is needed to boost testosterone production; while it will resume naturally, Tamoxifen can accelerate and enhance this process.
For breast cancer patients, the functionality of Tamoxifen Citrate is more straightforward. Estrogen fuels cancer growth, and Tamoxifen Citrate hampers estrogen's ability to bind, effectively starving the cancer. This treatment approach is commonly initiated with an AI before a transition to a SERM like Tamoxifen Citrate. It is also used preventatively in individuals with a significant family history of breast cancer.
Side effects:
Common side effects include headaches, upset stomach, hot flashes, vaginal itching, bleeding, discharge or discomfort, rash, reduced white blood cell count, endometrial changes, elevated triglyceride levels, and the risk of pulmonary embolism.
How to use:
In breast cancer treatment, there are six Tamoxifen Citrate regimens tailored for both men and women. Typically, doses range from 10-20 mg taken twice daily. A common initial dosage is 40 mg per day (20 mg twice daily). Many breast cancer patients may continue with a maintenance dose of 10-20 mg per day indefinitely after cancer remission to prevent recurrence.For anabolic steroid users, a standard preventive dose during cycles for gynecomastia is 10-20 mg per day. If this dosing does not alleviate symptoms, considering AIs might be necessary.
In terms of PCT, most plans will start with doses of 40 mg Tamoxifen Citrate per day for 2-3 weeks, followed by a reduction to 20 mg per day for an additional 2-3 weeks. A comprehensive PCT plan often incorporates another SERM, Clomiphene Citrate (Clomid). For more details on effective PCT strategies, please refer to "How to Come off Steroids."
