Commonly known as an anti-estrogen, Tamoxifen Citrate functions as both an antagonist and agonist. This means it can inhibit estrogen activity in certain parts of the body while mimicking it in others.
This medication is frequently utilized by anabolic steroid users, though it is not classified as a steroid. It is often employed during steroid cycles to mitigate estrogen-related side effects stemming from specific steroids. Its primary application is during Post Cycle Therapy (PCT).
Effects of Tamoxifen
For users of anabolic steroids, the positive effects of Tamoxifen Citrate can be experienced during and after steroid use, especially in the post-use phase. While it does not decrease overall estrogen levels, it binds to estrogen receptors in the breast area, preventing estrogen from exerting its effects there. However, it may not significantly reduce water retention, and some men may find it inadequate for preventing gynecomastia, depending on individual estrogen levels and genetic factors. For more robust protection, Aromatase Inhibitors (AIs) are suggested.
Another important effect of Tamoxifen Citrate is its ability to stimulate testosterone production. This is particularly vital for anabolic steroid users, who often experience suppressed natural testosterone levels during steroid cycles. As a result, nearly all steroid regimens include external testosterone to counteract this negative feedback loop. After completing a steroid cycle, additional measures are usually necessary to reactivate testosterone production. While this will eventually happen naturally, Tamoxifen can enhance both the speed and efficiency of this recovery.
For breast cancer patients, the effects of Tamoxifen Citrate are arguably more straightforward compared to anabolic steroid users. Estrogen can promote cancer growth; however, Tamoxifen Citrate blocks estrogen from binding, thereby inhibiting cancer growth. This method of treatment is both simple and effective. It is important to note that Tamoxifen is often used in conjunction with other medications; typically, treatment may start with an Aromatase Inhibitor and then transition to a Selective Estrogen Receptor Modulator (SERM) like Tamoxifen Citrate. It may also be used as a preventative option for individuals with a significant family history of breast cancer.
Side effects:Common side effects may include headaches, nausea, hot flashes, vaginal itching, bleeding or discharge, rashes, reduced white blood cell counts, endometrial alterations, increased triglycerides, and risk of pulmonary embolism.Dosage guidelines:
In the context of breast cancer treatment, there are six dosage plans applicable to both men and women. Typically, daily doses range from 10 to 20mg, taken twice daily. A dosage of 40mg per day (20mg twice daily) is commonly prescribed during the initial treatment phase. Many breast cancer patients may continue with 10-20mg daily on a long-term basis to avert recurrence after achieving remission.For anabolic steroid users seeking to prevent gynecomastia during their cycles, the usual dose is 10-20mg per day. If this does not alleviate symptoms, it may be necessary to consider Aromatase Inhibitors (AIs).
For Post Cycle Therapy (PCT), most plans begin with doses of 40mg per day for 2 to 3 weeks. Subsequently, the dose is usually decreased to 20mg per day for another 2 to 3 weeks. Effective PCT often involves other SERMs such as Clomiphene Citrate (Clomid). For a comprehensive guide on PCT, please refer to "How to Come off Steroids."
