Commonly identified as an anti-estrogen, Tamoxifen Citrate actually functions as both an antagonist and agonist. This means it inhibits estrogen activity in some parts of the body while acting like estrogen in others.
Although it is utilized by numerous anabolic steroid users, Tamoxifen Citrate is not a steroid itself. Many steroid users may employ it during their steroid cycles to mitigate estrogen-related side effects resulting from certain steroids. However, its primary application is during Post Cycle Therapy (PCT).
Effects of Tamoxifen
For users of anabolic steroids, the beneficial effects of Tamoxifen Citrate can be observed both during and after steroid usage, with a focus on the post-use period. Though Tamoxifen Citrate does not reduce serum estrogen levels, it binds to receptors in the breast, blocking estrogen from doing so. It is not particularly effective against water retention issues and may not provide sufficient gynecomastia prevention for all men; this effectiveness is influenced by individual estrogen levels and genetic factors. If stronger protection is required, Aromatase Inhibitors (AIs) are suggested.
Tamoxifen Citrate also has testosterone-stimulating effects, which are crucial for anabolic steroid users. The use of anabolic steroids suppresses natural testosterone production, a common consequence regardless of the steroids chosen. Thus, most steroid cycles incorporate exogenous testosterone to counteract potential low testosterone levels resulting from negative feedback. After steroid use concludes, something is needed to restart testosterone production. While this will happen naturally, it can be a slow process; Tamoxifen may both accelerate and enhance this recovery.
For breast cancer patients, the effects of Tamoxifen Citrate are even more straightforward. Cancer cells often thrive on estrogen, but Tamoxifen Citrate prevents estrogen from binding, thereby starving the cancer. This is a simple but effective treatment approach. While this is not the only medication used for treatment, it is often initiated with an AI and later switched to a SERM like Tamoxifen Citrate. Additionally, it may be used preventively for individuals with a strong family history of breast cancer.
Potential side effects:Headaches, nausea, hot flashes, vaginal itching, bleeding, discharge or discomfort, rashes, reduced white blood cell count, uterine changes, increased triglyceride levels, pulmonary embolism.Usage guidelines:
For treating breast cancer, there are six treatment regimens involving Tamoxifen Citrate for both male and female patients. In these plans, typical doses range from 10-20mg taken twice daily. A common initial dose is 40mg per day (20mg twice daily), especially at the commencement of treatment. After achieving remission, many breast cancer patients may continue with 10-20mg daily indefinitely to prevent recurrence.For anabolic steroid users, the recommended dosage for gynecomastia prevention while on cycle is also 10-20mg per day. If this dosage range is ineffective, it is unlikely that a higher dose will help, and AIs should be strongly considered.
In terms of PCT, most protocols start with doses of 40mg per day of Tamoxifen Citrate for 2-3 weeks, followed by a reduction to 20mg per day for an additional 2-3 weeks. A comprehensive PCT plan often incorporates another SERM, Clomiphene Citrate (Clomid). For a complete outline on how to properly conclude steroid use, refer to How to Come Off Steroids.