Commonly known as an anti-estrogen, Tamoxifen Citrate functions as both an antagonist and agonist. It acts as an anti-estrogen in some parts of the body while behaving like estrogen in others.
Although frequently utilized by users of anabolic steroids, Tamoxifen is not a steroid itself. It is often administered during steroid cycles to address estrogen-related side effects triggered by certain steroids but is most prevalently used in Post Cycle Therapy (PCT).
Effects of Tamoxifen
For users of anabolic steroids, the advantageous effects of Tamoxifen Citrate can be observed both during and after steroid use, with a primary focus on the latter. While it doesn't reduce overall estrogen levels in the bloodstream, it binds to receptors in the breast tissue, preventing estrogen from attaching. This may not significantly affect water retention concerns and may not provide adequate protection against gynecomastia for all men, as susceptibility can vary based on estrogen levels and genetic factors. If stronger protection is desired, Aromatase Inhibitors (AIs) are suggested.
Additionally, Tamoxifen Citrate has testosterone-stimulating effects, which are crucial for anabolic steroid users. Anabolic steroid use suppresses natural testosterone production, necessitating the inclusion of exogenous testosterone in most steroid cycles to avoid low testosterone levels. After completing steroid use, a method to reactivate testosterone production is essential. While it can resume naturally, it may be gradual, and Tamoxifen can accelerate and enhance this process.
For patients with breast cancer, the effects of Tamoxifen Citrate are clearer compared to anabolic steroid users. Estrogen fuels the cancer, but Tamoxifen Citrate blocks its attachment, effectively starving the cancer cells. This approach is simple yet effective. Treatment typically starts with an Aromatase Inhibitor (AI) and may transition to a Selective Estrogen Receptor Modulator (SERM) like Tamoxifen Citrate. Additionally, it might be used as a preventive measure for individuals with a significant family history of breast cancer.
Side effects:Possible side effects include headaches, nausea, hot flashes, vaginal itching, bleeding, discharge or discomfort, skin rashes, reduced white blood cell count, endometrial changes, increased triglyceride levels, and risk of pulmonary embolism.How to use:
In breast cancer treatment, there are six Tamoxifen Citrate regimens for both male and female patients, typically involving doses of 10-20mg taken twice daily. A common initial dose is 40mg per day (20mg twice daily). Many breast cancer patients may continue with a daily dose of 10-20mg indefinitely after remission to prevent recurrence.For anabolic steroid users, a standard dosage for gynecomastia prevention during cycles is 10-20mg daily. If this dosage is ineffective, considering Aromatase Inhibitors (AIs) may be important.
In the context of PCT, most plans start with a dosage of 40mg per day for 2-3 weeks, followed by a reduction to 20mg per day for an additional 2-3 weeks. A proper PCT regimen often includes another SERM, Clomiphene Citrate (Clomid). For more detailed guidance on PCT, please refer to guidelines on how to come off steroids.