Strong gonadotropin stimulator/mild anti-estrogen Clomiphene is a synthetic estrogen clinically administered to help womenovulate. Bodybuilders, (male) following AAS cycles, seeking to jump start naturaltestosterone production (or those that were simply seeking a natural testosterone spike)have used this drug with great success. Clomiphene increases activity in thehypothalamus-pituitary-gonadol axis by stimulating the release of more gondotropin fromthe pituitary gland. Therefore, a higher/faster level of LH (luteinizing hormone) and FSH(follicle stimulating hormone) results. This creates a signal to the leydig cells in the testeswhich in turn produce more testosterone and sperm. Normally with Clomiphene this took5-15 days. Most started with 50-mg twice daily for about 5 days, then reduced intake to50 mg once a day for 5-10 more days. Due to Clomiphene providing a fast response time,I felt it was often beneficial to use a dosage of 100 mg total daily for 5 days, mid-cycleduring longer AAS protocols. This drug was seldom utilized for longer than 15 dayscontinuously simply due to it being unnecessary. The goal was to normalize testosteroneproduction post AAS cycle as quickly as possible so as to minimize post-cycle strengthand mass loss. Not create dependency.HCG was combined with Clomiphene (Clomid) sometimes, or Clomiphene wasused after HCG administration. This is because Clomiphene acts by affecting thehypothalamus and pituitary (hypophysis) and regenerating the whole regulating system,while HCG only "imitates" LH, thus stimulating the leydig cells in the testes to producenatural testosterone. (*Also see HCG)*Some may wonder about Clomiphene being a synthetic estrogen. Yes, it is, but itworks as an anti-estrogen. This is due to the fact that Clomiphene has a very low estrogeniceffect. This means stronger and more active estrogen, such as those formed during thearomatization of many androgenic steroids, are blocked out of the receptor-site and lessestrogenic activity results; less gyno, less water retention. Clomiphene was by no means aseffective as Novladex or Proviron for estrogen suppression, but post-cycle it helped greatly.